Anticonvulsant and Depressant Activities of Ethanol Leaf Extract of Solanum Anomalum (Solanaceae)
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The ethanol leaf extract of Solanum anomalum (70-210 mg/kg) was evaluated for anticonvulsant activity in mice using pentylene tetrazol and aminophylline models as well as depressant activity using open field, forced swimming and Tail suspension tests. The leaf extract significantly (p<0.005-0.001) inhibited convulsions induced experimentally in all the models tested in a dose-dependent fashion. The leaf extract further caused increases in the frequencies of line crossing, walling and rearing activities of mice. The immobility time of mice during forced swimming and tail suspension tests was also increased. The findings of this study show that the leaf extract possesses anticonvulsant and depressant activities which confirms its use in traditional medicine in the treatment of CNS disorders.
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