Formulation of Persea americana seed extract into tablet dosage

Résumé

Formulation of ethanol seed extract of Persea americana Mill (Family Lauraceae) into tablet dosage form was investigated. Formulation into tablets was done by direct compression using lactose and microcrystalline cellulose (Avicel) as directly compressible diluent and wet granulation using 4% solutions of gelatin and polyvinyl pyrrolidone (PVP) as binders. Tablets were compressed at 10, 15 and 20 kN and later subjected to tablet quality testing procedures. The mechanical properties of the tablets were assessed using crushing strength (CS) and friability (F) and the crushing strength – friability ratio (CSFR) while drug release properties were evaluated using disintegration and dissolution times. There were statistically significant (p < 0.01) differences in the crushing strength (CS) values and drug release properties of P. americana prepared by both methods. Tablets containing Avicel produced better mechanical properties than tablets containing lactose. Tablets containing PVP as binder possessed better and more consistent release properties than tablets containing gelatin. Tablets produced by direct compression possessed better mechanical and release properties than tablets produced by wet granulation. The method of preparation of the P. americana tablets needs to be carefully selected to ensure the production of tablets with adequate bond strength and the same time release its active contents for pharmacologic action.