Mechanical and Release Properties of Paracetamol Tablets Formulated With Some Natural and Modified Starch Mucilages

Main Article Content

Adedokun Musiliu
Itiola Oludele

Abstract

Mechanical and release properties of paracetamol tablets formulated with mucilages of natural and pregelatinized forms of trifoliate yams, rice and standard corn starch BP have been evaluated. Tensile strength (T) and degree of brittleness (BFI) were employed to assess the mechanical properties of the tablets while disintegration time (Dt) and dissolution profiles (ti, t80, k1 and k2) were used to study their release properties. Results of the evaluation showed that tablets containing pregelatinized starches had lower T but also lower BFI than those formulated with natural starch binders. Values of disintegration time Dt and t80 (the time for 80% paracetamol to be released) were generally higher for formulations containing natural starch binders than those containing pregelatinized binders. The rate of drug release, as expressed by the dissolution rate constants k1 and k2, were higher for formulations containing pregelatinized binders, with k2 being generally higher than k1. Statistically, there were significant differences (p<0.05) between the values of these parameters for natural and pregelatinized
starch binders. The ranking of T and t80 for all the starch binders was corn > yellow T. yam > white T. yam > rice. For BFI, the ranking was yellow T. yam < corn < white T. yam < rice. These results suggest that mucilages of natural and pregelatinized starches from white and yellow trifoliate yams and rice are suitable as binders in paracetamol tablet production and may even perform better than corn starch BP in some formulations.

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How to Cite
Musiliu, A. ., & Oludele, I. . (2020). Mechanical and Release Properties of Paracetamol Tablets Formulated With Some Natural and Modified Starch Mucilages. Nigerian Journal of Pharmaceutical and Applied Science Research, 1(2), 46–66. Retrieved from http://mail.nijophasr.net/index.php/nijophasr/article/view/25
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Articles
Author Biographies

Adedokun Musiliu

Department of Pharmaceutics and Pharmaceutical Technology,
Faculty of Pharmacy, University of Uyo, Akwa-Ibom State, Nigeria.

Itiola Oludele

Department of Pharmaceutics and Industrial Pharmacy,
Faculty of Pharmacy, University of Ibadan, Ibadan, Nigeria.

References

Adedokun MO, Itiola OA (2010). Material properties and compaction characteristics of natural and pregelatinized forms of four starches. Carbohydrate Polymers, 79: 818–824.

Alebiowu G, Itiola OA (2001). Effects of Natural and Pregelatinized Sorghum, Plantain and Corn Starch Binders on the Compressional

Characteristics of a Paracetamol Tablet Formulation. Pharmaceutical Technology (Suppl. Ed: Drug Delivery): 26-30

Alebiowu G, Itiola OA (2002). Compressional Characteristics of Native and Pregelatinized Sorghum, Plantain and Corn Starches and the Mechanical Properties of their Tablets. Drug development & Industrial Pharmacy, 28(6): 663- 672.

Ayernor GS (1985). The Yam (Dioscorea) Starches. In Godson Osuji (ed) Advances in Yam Research – The Biochemistry and Technology of the Yam Tuber. Biochemical Society of Nigeria in Collaboration with Anambra State University of Technology, pp 79-88. British Pharmacopoea Vols. I and II (1998). Her Majesty’s Stationery Office, London.

Buleon A, Colonna P, Phanchot V, Ball S (1998). Starch Granules: Structure and Biosynthesis. International Journal of Biological Macromolecules, 23: 85-112.

Caramella C, Colombo P, Bettinetti GP, Giordano F, Conte U, La Manna A. (1984). Swelling Properties of Disintegrants. Acta Pharm. Technol. 30(2): 132-139.

Ek R, Lennholm H, Davidson R, Nystrom C, Ragnarsson G (1995). Pore Swelling in Beads made of Cellulose Fibre and Fibre Fragments. International Journal of Pharmaceutics, 122: 49-56.

Evans WC (2002). Carbohydrates. In W.C. Evans and D. Evans (eds.) Trease and Evans Pharmacognosy. 15th ed. W.B. Saunders, Ediburgh, pp 191-213.

Fell JT, Newton JM, (1970). Determination of Tablet Strength by Diametral Compression Test. Journal of Pharmaceutical Sciences, 59: 688-691.

Ferrari F, Bertoni M, Bonferoni MC, Rossi S, Caramella C, Nystrom C (1996). Investigation on Bonding and Disintegration Properties of Pharmaceutical Materials. International Journal of Pharmaceutics, 136: 71-79.

Garr JSM, Bangudu AB, (1991). Evaluation of Sorghum Starch as a Tablet Excipient. Drug Development & Industrial Pharmacy, 17(1): 1-6.

Hiestand EN, Wells JE, Poet CB, Ochs JF (1977). Physical Processes of Tableting. Journal of Pharmaceutical Sciences, 66: 510-519.

Itiola OA, Pilpel N, (1986a). Studies on Metronidazole Tablet Formulations. Journal of Pharmacy & Pharmacology, 38: 81-86.

Itiola OA, Pilpel N, (1986b). Tableting Characteristics of Metronidazole Formulations. International Journal of Pharmaceutics, 31: 99-

Jacobs H, Delcour JA, (1998). Hydrothermal Modifications of Granular Starch, with Retention of the Granular Structure: A Review. J. Agric. Food Chem., 46(8): 2895-2905.

Kitazawa S, Johno I, Ito Y, Teramura S, Okada J (1975). Effects of Hardness on the Disintegration and Dissolution Rate of Uncoated Caffeine Tablets. Journal of Pharmacy & Pharmacology, 27: 765-770.

Kitazawa, S., Johno, I., Minouchi, T. and Okada, J. 1977. Interpretation of Dissolution Rate Data from Vitro Testing of Compressed Tablets. Journal of Pharmacy & Pharmacology, 29: 453-459.

Kottke MK., Chueh HR, Rhodes, CT, (1992). Comparison of Disintegrant and Binder Activity of Three Corn Starch Products. Drug Development & Industrial Pharmacy, 18: 2207-2223.

Kurup TRR, Pilpel N, (1979). The Effects of Binding Agents on the Tensile Strength of Powders and Tablets. Asian J. Pharm. Sci., 1: 75-90.

Luangtana-Anan M, Fell JT (1990). Bonding Mechanisms in Tableting. International Journal of Pharmaceutics, 60: 197-202.

Nkala D, Sibanda S, Tomasik P, Palasinski M (1994). Isolation and Properties of Starch from Wild Yam from Zimbabwe. Starch/Starke, 46(3): 85-88.

Odeku OA, Itiola OA, (1998). Evaluation of Khaya Gum as a Binder in a Paracetamol Tablet Formulation. Pharmacy & Pharmacology Communications, 4: 183-188.

Odeku OA, Itiola OA, (2002). Characterization of Khaya Gum as a Binder in a Paracetamol Tablet Formulation. Drug Development & Industrial Pharmacy, 28(3): 329-337.

Odeku OA, Awe OO, Popoola B, Odeniyi MA, Itiola OA (2005). Compression and Mechanical Properties of Tablet Formulations Containing Corn, Sweet Potato and Cocoyam Starches as Binders. Pharmaceutical Technology, 29(4): 82-90.

Pilpel N, Otuyemi SO, Kurup TRR (1978). Factors Affecting the Disintegration and Dissolution of Chloroquine Phosphate/Starch Tablets. Journal of Pharmacy & Pharmacology, 30: 214-219.

The Pharmaceutical Codex (1979). The Pharmaceutical Society of Great Britain, London. The United States Pharmacopoeia (2000).

Thomas DJ, Atwell WA (1999). Starches: Practical Guides for the Food Industry. American Association of Cereal Chemists, St. Paul, Minnesota, USA, pp. 19-22.

Upadrashta SM, Katikaneni PR, Nuessle NO (1992). Chitosan as a Tablet Binder. Drug Development & Industrial Pharmacy, 18: 1701- 1708.

Whistler RL, BeMiller JN, (1997), Carbohydrate Chemistry for Food Scientists. St. Paul, Eagan Press, pp. 117-151.

Zobel HF, Stephen AM, (1995). Starch Structure, Analysis and Application. In: Stephen AM ed, Food Polysaccharides and their Applications. Marcel Dekker Inc., pp. 19-65.