Formulation of subcutaneous implantable drug delivery system of ibuprofen using biodegradable polymers
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Résumé
Background: The purpose of this study was to formulate subcutaneous implantable drug delivery system of ibuprofen using biodegradable polymers and to evaluate the formulated implants using in vitro and in vivo models.
Methods: The solvent casting technique was used in the formulation of the implants with gelatin-hydroxypropyl methylcellulose (HPMC) admixture (80:20) as the polymer blend. The plasticizing agent used was glycerin. The physicochemical properties of the implants were evaluated. The implants in vivo analgesic effect on acetic acid-induced mouse writhing in mice was also investigated.
Results: The implant pellets were similar in appearance with minimal variation from batch to batch. The mean diameter/thickness of the implants ranged from 2.60 ± 0.10 - 2.85 ± 0.20 mm, the mean percentage drug content was 96.40 ± 0.10% and the swelling index values were 2.98 ± 0.12 – 4.86 ± 0.11%. In comparison to the control, the in vivo analgesic effect of the ibuprofen implants significantly reduced acetic acid-induced writhing in mice.
Conclusion: The results of this study demonstrated that the solvent casting technique can be used in the formulation of ibuprofen biodegradable implants that can be used in the management of chronic diseases such as arthritis.
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