Determination of Aspirin Stability in oil in Water Emulsion prepared using different oils and Gums.

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Publié-e : sept. 1, 2020
Mots-clés :
Aspirin, Emulsion, Oils, Okra mucilage

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Afokoghene Avbunudiogba John
Ikhuoria Arhewoh Matthew
Okiemute Imonije Juliet

Résumé

The poor stability of aspirin in aqueous medium is a major drawback in the formulation of aspirin in liquid dosage form. This study is aimed at formulating stable oil preparation of aspirin with okra (Abelmoschus esculentus L) mucilage as emulsifying agent. The emulsion was formulated by dispersing the aspirin in the oily phase which was then dispersed in the aqueous continuous phase. The specific density, pH, organoleptic properties and aspirin content of the emulsions were evaluated. The effect of the okra mucilage was compared to acacia which serve as a standard natural emulsifying agent. Emulsions of acacia gave pH of 3.18, 3.31, and 3.35 compared to those of okra mucilage (O.M) with pH of 3.11, 3.10 and 3.06. The percentage content and stability were better in olive oil emulsion compared to emulsions made of palm oil and shea butter. The organoleptic properties of the formulations varied with the viscosity of the oils. This study showed that aspirin and okra mucilage have good compatibility with olive oil, which can serve as a means of formulating aspirin emulsion to enhance compliance in children. O.M can be useful in formulating stable emulsions when combine with other natural emulsifiers in small quantities.

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John , A. A., Matthew , I. A., & Juliet , O. I. (2020). Determination of Aspirin Stability in oil in Water Emulsion prepared using different oils and Gums. Nigerian Journal of Pharmaceutical and Applied Science Research, 9(3), 40–45. Consulté à l’adresse http://mail.nijophasr.net/index.php/nijophasr/article/view/358
Numéro
Vol. 9 No. 3 (2020)
Rubrique
Articles
Licence Creative Commons

Cette œuvre est sous licence Creative Commons Attribution - Pas d'Utilisation Commerciale - Pas de Modification 4.0 International.

Bibliographies de l'auteur-e

Afokoghene Avbunudiogba John

Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmacy, Delta State University, Abraka

Ikhuoria Arhewoh Matthew

Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Benin, Benin City.

Okiemute Imonije Juliet

Department of Pharmaceutics and Industrial Pharmacy Faculty of Pharmacy, Delta State University, Abraka

Références

Anglolillo DJ, Bhatt DL, Lanza F, Cryer B, Dong J, Jeske W, Zimmerman RR, Chong E, Prats J, Dellargyris EN, Marathl U. Pharmacokinetic/Pharmacodynamic assessment of a novel pharmaceutical liquid aspirin complex: Results of a randomized crossover, bioequivalence study. Journal of Thrombosis and Thrombolysis; extracted on September 5, 2019 from: https://dol.org/10./1007/s11239-019-01933-7

Arnold H, Gartner DDS (1976). Aspirin induced gastritis and gastrointestinal bleeding. J. Am Den. Ass. 93(1): 111 – 117.

Avbunudiogba JA, Okor RS, Uhumwangho MU, Arhewoh MI (2012). Melt granulation of aspirin powder as an alternative to slugging: implication for compressibility and dissolution rate. Nig. J. Pharm. Sc. 11(1): 23-30.

Avbunudiogba JA, Okor RS, Uhumwangho MU, Arhewoh MI (2013). Protective effects of waxes on aspirin tablets against moisture. Afr. J. Pharm. Res. & Dev. 5(2): 99-104.

British Pharmacopoeia. Aspirin tablet. 2012; 187-188.

Cryer B, Mahaffey KW (2014). Gastrointestinal ulcers, role of aspirin and clinical outcomes: Pathobiology, diagnosis and treatment. J. Multidis Healthcare. 7: 137 – 146.

Eichel HJ and Massmann BD (1987). Sustained release pharmaceutical preparations containing a water-soluble drug, especially aspirin with enteric – sustained release protective coating, European PatentApplication, 13pp, Patent index EP 239361A1, 870-930.

Emeje MO, Isimi CY and Kunle OO (2007). Evaluation of okra gum as a dry binder in paracetamol tabket formulation. Cont. J. Pharm. Sc. 1: 15-22.

Ezeuko SA, Bamgboye AO, Ademosun TO, Okedere PA (2018). Cosmetics Emulsion from African Nutmeg oil (Monodora myristica): Formulation, Chemical Evaluation and Microbiological Analysis. Int. J. Chem. Pharm. Sc. 6(5): 151-156.

Farges M. U.S. patent 3, 316, 150, Feb. 26, 1964.

Holt PR. Dimethyl isosorbide in liquid formulation of aspirin (1959). Proc. Soc. Exp. Biol. Med. 102: 517.

Huang ES, Strate LL, Ho WW, Lee SS and Chan AT (2011). Long term use of aspirin and the risk of gastrointestinal bleeding. Am. J. Med. 124(5): 426 – 433.

Khan BA, Akhtar N, Khan HMS, Waseem K, Mahmood T, Rasul A et al (2011). Basics of Pharmaceutical Emulsion: A review. Afr. J. Pharm. Pharmacol. 5(25): 2715-2725.

Mitchell SH, Schaefer DC and Dubagunta S (2004). A new view of occult and obscure gastrointestinal bleeding. Am. fam. Physi. 69(4): 875-881

Onah JO (2004). The Kinetics of hydrolysis of acetyl salicylic acid (aspirin) in different polar media. Glob. J. P. & A. Sc. 10(2): 297-300.

Patel RP, Patel KP, Modi KA, Pathak CJ (2013). Formulation, development and evaluation of injectable formulation of aspirin. Drg. & Thera. St. 3(e2): 6 - 12.

Pharmaceutical Codex (1979). 11th Edition. Pp.1290.

Ravi Kr, Patil MM, Sachin RP, Mahesh SP (2009). “Evaluation of Abelmoschus esculentus mucilage as suspending agent in paracetamol suspension”. Int. J. PharmTech. Res. 1(3): 658-665.

Strassner JE (1968). Effect of pH on interfacial films and stability of crude oil – water emulsions. J. Pet. Technol. 20(3): 303 – 312.

Tomski HW, Waller LS (1940). Dimethlisosorbide in liquid formulation of aspirin. Pharm J. 144: 53.

Venkateswarlu V (2010). Biopharmaceutics and Pharmacokinetics. 2nd edn, Sultan Bazar, Hyderabab, PharmaMed Press. Pp 5 - 96.

Wessi A, Pitman ER, Granam EC (1961). Aspirin and gastric bleeding: Gastroscopic observations with review of the literature. Am. J. Med. 31: 266.