Oral dissolving films of Chlorpheniramine maleate from Wheat Starch/Polymer Blends
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Résumé
The aim of this work was to prepare oral dissolving films of Chlorpheniramine maleate using starch/polymer blends.
Formulations of oral disintegrating films of chlorphenarime maleate were prepared from native (NAT), pregelatinised (PGL) and
freeze-dried (FRD) wheat starches blended with hydroxypropylmethyl cellulose (HPMC). The material and rheological
properties of blends of native and modified forms of the native and modified starches and the blended mixtures were
determined. Modified starches were mixed with HPMC to form the starch/polymer blends. Chlorphenirame maleate was
incorporated into the starch-polymer blends by dissolution. Films were obtained through the solvent evaporation method and
evaluated for strength and drug release. The ranking for viscosity for the blends was NAT/HPMC > FRD/HPMC > PGL/HPMC.
Film flexibility ranged from 18 to 41 in the order PGL/HPMC> NAT/HPMC > FRD/HPMC. Drug release for all films was within
10minutes. Flexible oral disintegrating film formulations of chlorpheniramine maleate were obtained from the wheat
starch/HPMC blends.
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Références
Adedokun MO, Itiola OA. (2010). Material properties and compaction characteristics of natural and pregelatinized forms of four starches. Carbohydrate Polymers 79: 818–824.
Akhila RT, Emila A (2006). Enzymatic modification of cassava starch by bacterial lipase. Bioprocess Biosyst. Eng. 29: 65-69.
Akintayo CO, Akintayo ET (2009). Preparation, composition and physico-chemical characteristics of native, oxidized and acetylated african yambean (Sphenostylis sternocarpa) starches. Advances in Natural and Applied Sciences, 3(2): 196-203.
Alur HH, Johnston TP, Mitra AK. (2001). Peptides and Proteins: Buccal Absorption. in: Swarbrick J, Boylan J.C, ed. Encyclopedia of Pharmaceutical Technology vol. 20 (3), Marcel Dekker Inc., New York, , pp, 193-218.
Betancour-Ancona, D, Guerrero LC, Hernandez EC (1997). Acetylation and characterization of Canavalia ensiformis starch. Journal of Agric and Food Chemistry 45:378-382.
Cascone MG, Barbani N, Cristallini C, Giusti P, Ciardelli G, Lazzeri L (2001). Bioartificial polymeric materials based on polysaccharides. J Biomaterials Science, Polymer Edition 12: 3, 267–281.
Chinna R P, Madhusudan RY. (2010). Buccal Drug Delivery Systems. In: Madhusudan Rao Y, Jithan A.V. ed. Advances in drug delivery. 1: 139-210.
Doane WM. (1992). USDA research on starch-based biodegradable plastics. Starch. 44:293–295.
Hashim K., Dahlan K.Z. and Noordin N.M (2000). Hydrogel of sago starch/water-soluble polymers by electron beam irradiation technique. International Symposium on Radiation Technology in Emerging Industrial Applications, pp. 79–80. International Atomic Energy Agency(IAEA)-SM-365.
Kunal P, Banthia AK, Majumdar DK (2006). Starch based hydrogel with potential biomedical application as artificial skin. Afr. J. Biomedical Research, 9: 23 – 29.
Lyons JG, Geever LM, Nugent MJ, Kennedy JE, Higginbotham CL. (2009). Development and characterisation of an agar--polyvinyl alcohol blend hydrogel. J Mech Behav Biomed Mater. 2(5):485-93.
Odeniyi MA, Ayorinde JO (2012). Material and rheological properties of yam starch/polymer blend hydrogels. International Journal of Pharmacology and Pharmaceutical Technology, 1 (2): 23-28.
Odeniyi M A, Onu RN, Adetunji OA (2011a). Evaluation of bioadhesive properties of natural and modified banana starches. East and Central African Journal of Pharmaceutical Sciences 14 (2): 34-42.
Odeniyi MA, Atolagbe FM, Aina OO, Adetunji OA (2011b). Preliminary evaluation of mucoadhesive properties of native and modified starches of the root tubers of cocoyam (Xanthosoma sagittifolium). African Journal of Biomedical Research 14 (3):169-174.
Riley CK, Adebayo SA (2010). A comparative investigation of the packing and flow properties of sweet potato (Ipomea batatas) starches and their potential uses in solid dosage formulations. Starch-Starke. 62:285-293.
Seide CW, Kulicke M, Heß C, Hartmann B, Lechner MD, Lazik W (2001). Influence of the cross-linking agent on the gel structure of starch derivatives. Starch/Stärke 53(7):305–310.
Shogren RL, Fanta GF, Doane WM (1994). Development of starch based plastics—a re-examination of selected polymer systems in historical perspective. Starch 45:276–280
Thomas DJ, Atwell WA (1999). In Starches: Practical guides for the food industry (pp. 19–22). St. Paul, Minnesota, USA: American Association of Cereal Chemists.
Toshio Y, Rumi Y, Chieko S, Rumiko F (2006). Synthesis and characterization of biodegradable hydrogels based on starch and succinic anhydride. Carbohydr. Polym. 64:(2) 345–349.
Zhang LM, Wang GH, Lu HW, Yang C, Yan L (2005). A new class of starch-based hydrogels incorporating acrylamide and vinyl pyrrolidone: Effects of reaction variables on water sorption behavior. J. Bioact. Compat. Polym. 20:(5) 491–501.