Antinociceptive and Antipyretic activity of leaf extract of <em>Lasianthera Africana</em>

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Jude Efiom Okokon
Godwin Ndarake Enin
Ofonime Emmanuel Udofia
Louis U. Amazu

Résumé

The leaf of Lasianthera africana is used commonly for nutritional purposes and medicinally in the treatment of fever, malaria and inflammatory diseases. The ethanol leaf extract of Lasianthera africana (500 - 1500 mg/kg) was evaluated for analgesic and antipyretic activities against acetic acid-induced writhing, formalin-induced hind paw licking, thermal – induced pain, amphetamine and yeast - induced pyrexia models. The dichloromethane fraction was also analyzed using Gas chromatography-mass spectrometry (GCMS). The leaf extract exhibited a dose-dependent inhibition of pains in the three experimental models and significant (p<0.01) inhibition of pyrexia induced by amphetamine and yeast. The GCMS analysis revealed the presence of pharmacologically active compounds which are likely responsible for the observed activities suggesting that the leaf extract possess analgesic and antipyretic properties.

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Efiom Okokon, J. ., Ndarake Enin, G. ., Emmanuel Udofia, O. ., & U. Amazu, L. . (2020). Antinociceptive and Antipyretic activity of leaf extract of <em>Lasianthera Africana</em>. Nigerian Journal of Pharmaceutical and Applied Science Research, 2(1), 17–24. Consulté à l’adresse http://mail.nijophasr.net/index.php/nijophasr/article/view/30
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Jude Efiom Okokon

Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria

Godwin Ndarake Enin

Department of Chemistry, University of Uyo, Uyo, Nigeria

Ofonime Emmanuel Udofia

Department of Pharmacology and Toxicology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria

Louis U. Amazu

Department of Pharmacology and Therapeutics, College of Medicine, Evans Enwerem University, Orlu Campus

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