Albizia zygia (D.C.) Macbr (Fabaceae): A Comparative Investigation of Phytochemical Composition, Proximate Analysis and Anti- Seizure Properties of Methanol Extracts of Its Leaves and Stem-Bark.

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J. O. Uwaya
L. O. Okunrobo
P. O. Igbinaduwa

Résumé

Albizia zygia belongs to the legume subfamily Mimosoideae. Albizia lebbecka, a congener of Albizia zygia is reported to possess anti-seizure activity and folk reports of sedation when the leaves of Albizia zygia are consumed. This aim of this study was to compare the phytochemistry, proximate parameters and possible anti-seizure properties of the methanol extracts of the leaves and stem-bark of Albizia zygia. Phytochemical screening and proximate analysis were carried out according to standard methods. Pentylentetrazol (PTZ) and maximum electroshock (MES) test were employed to investigate the anti-seizure properties in mice at 200, 400 and 800 mg/kg doses. Both samples had saponins and flavonoids in common but phenols were only present in the leaves while alkaloids, tannins and proteins were found only in the stem-bark. Anti-seizure activity of the stem-bark was superior to that of the leaves and was significant (p<0.05) in the PTZ test. This study lends support to the ethnomedicinal use of the plant in the management of seizures.

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Uwaya , J. O., Okunrobo , L. O., & Igbinaduwa , P. O. (2020). Albizia zygia (D.C.) Macbr (Fabaceae): A Comparative Investigation of Phytochemical Composition, Proximate Analysis and Anti- Seizure Properties of Methanol Extracts of Its Leaves and Stem-Bark. Nigerian Journal of Pharmaceutical and Applied Science Research, 6(2), 76–80. Consulté à l’adresse http://mail.nijophasr.net/index.php/nijophasr/article/view/191
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J. O. Uwaya

Department of Pharmaceutical Chemistry, Faculty of Pharmacy; University of Benin, Benin City, Nigeria

L. O. Okunrobo

Department of Pharmaceutical Chemistry, Faculty of Pharmacy; University of Benin, Benin City, Nigeria

P. O. Igbinaduwa

Department of Pharmaceutical Chemistry, Faculty of Pharmacy; University of Benin, Benin City, Nigeria

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