Anti-Inflammatory And Anti-Nociceptive Effects Of The Methanol Root Extract Of Maniophyton fulvum Muell Arg. (Eupherbiaceae) In Albino Mice
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Résumé
Maniophyton fulvum is a herbaceous plant used in Akwa Ibom State, Nigeria to treat pains, frequent stooling and swellings. In this study, the methanol root extract of the plant was investigated for its phytochemical constituents, safety profile, anti-inflammatory and anti-nociceptive properties. The result of the phytochemical screening revealed that the plant contained flavonoids and terpenes. The median Lethal Dose (LD50) was 948.68 mg/kg. At a dose of 284.60 mg/kg the extract exhibited a significant (p<0.05) anti-inflammatory effect against oedema induced by egg-albumin and xylene. The dose also exhibited a significant (p<0.05) anti-nociceptive effect against acetic acid-induced writhing movement and formalin-induced hind paw licking in mice. The presence of flavonoids and terpenes in the plant is believed to cause the reduction in the inflammation and pain in the mice.
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