Synthesis, Characterization and Complexation of Sc(III) Ion Using Chloroquine Diphosphate Drug

Main Article Content

I. E. Otuokere
L. O. Okpara
N. Ikpo
G. U. Okafor
F. C. Nwadire
C. O. Olisa

Abstract

Chloroquine possess lone pairs of electrons that can be donated to central metal ion. Scandium (III) complex of chloroquine was synthesized by reaction of chloroquine diphosphate with scandium (III) oxide. The metal complex was characterized based on melting point, UV, IR, and 1H NMR Spectroscopy. 1H NMR Spectra of the complex further showed the involvement of the amine group in coordination to the metal complex. The IR spectra of the complex showed the involvement of amine and imine group in coordination to the metal. The electronic spectrum of the complex suggested intraligand charge transfer (ILCT), ligand to metal charge transfer (LMCT), and d-d transition. The melting point of the complex was higher than the free ligand. Spectroscopic studies showed that chloroquine acted as a bidentate ligand. These results showed that chloroquine has the ability to sequestrate Sc (III) ion from solution. We recommend the use of chloroquine in scandium extraction and chelation therapy.

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How to Cite
Otuokere, I. E. ., Okpara, L. O. ., Ikpo, N. ., Okafor, G. U. ., Nwadire, F. C. ., & Olisa, C. O. . (2020). Synthesis, Characterization and Complexation of Sc(III) Ion Using Chloroquine Diphosphate Drug. Nigerian Journal of Pharmaceutical and Applied Science Research, 8(1), 38–43. Retrieved from http://mail.nijophasr.net/index.php/nijophasr/article/view/274
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Articles
Author Biographies

I. E. Otuokere

Department of Chemistry, Michael Okpara University of Agriculture, Umudike, Nigeria

L. O. Okpara

Department of Chemistry, Michael Okpara University of Agriculture, Umudike, Nigeria

N. Ikpo

Department of Chemistry, University of Alberta, Canada

G. U. Okafor

Department of Chemistry, Enugu State University of Science and Technology

F. C. Nwadire

Department of Chemistry, Michael Okpara University of Agriculture, Umudike, Nigeria

C. O. Olisa

Department of chemistry, Federal University of Technology, Owerri

References

Aaseth J., Skaug M.A., Cao, Y. and Andersen, O., (2015). Chelation in metal intoxication —Principles and paradigms, Journal of Trace

Elements in Medicine and Biology.31: 260-266.

Andersen, O. (2004). Chemical and biological considerations in the treatment of metal intoxications by chelating agents. Mini-Reviews

in Medicinal Chemistry, 4:11

Bradberry, S. and Vale A. (2009). A comparison of sodium calcium edentate (edentate calcium disodium) and succimer (DMSA) in the

treatment of inorganic lead poisoning. Clinical toxicology, 47: 841-858.

Jingping, W., Chengjun, W., Peiqi, W., Xiao, L., Zhang,M. and Zhu, J. (2017). Polypyrrole capacitance characteristics with different doping ions and thicknesses. Physical Chemistry Chemical Physics,19: 21165-21173

Knudtson, M. L., Wyse, G. and Galbraith, P. D (2002). Chelation therapy for ischemic heart disease: A randomized controlled trial.

Journal of the American Medical Association, 287(4): 481-486.

Kosnett, M. J (2010). Chelation for heavy metals (arsenic, lead, and mercury): protective or perilous? Clinical Pharmaceutical &

Therapeutics, 8: 412-415.

Mohammad,T. and Abdullah,A. A. (1984). Analytical Profiles of Drug Substances, volume 13, King Saud University, Riyadh, Saudi

Arabia.

Nadira, W., and Singh, H. B (1987). Synthesis of metal complexes ofantimalaria drugs and invitro evaluation of their activity. Inorg. Chim. Acta. 135: 134-137

Odiaka,T. I (2004). Modern Organometallic Chemistry, University Press PLC, Ibadan.18

Patrick, L. (2006). Lead toxicity, a review of the literature. Part 1. Exposure, evaluation and treatment. Alternative Medicine Review, 11: 2-22.

Pedrares, A.S., Romero, J., Vazquez, J.A.G., Duran, M.L. and Casanova, I. (2003). Electrochemical, synthesis and structural

characterisation of zinc, cadmium and mercury complexes of heterocyclic bidentate ligands (N, S). Dalton Transaction 7: 1379 - 1388.

Ratnaike, R. N. (2003). Acute and chronic arsenic toxicity. Postgraduate Medical Journal, 79: 391 - 396.

Reiss, A. and Mureseanu, M. (2012), Transition metal complexes with ligand containing thioamide moiety: Synthesis, characterization and antibacterial studies, Journal of Chilean Chemical Society, 57(4):1409 – 1414.

Ronnback, L. and Hansson, E. (1992). Chronic encephalopathies induced by low doses of mercury or lead. British Journal of Industrial

Medicine 49: 233-240.

Verstraeten, S. V., Aimo, L. and Oteiza, P. I. (2008). Aluminium and lead: molecular mechanisms of brain toxicity. Archives of

Toxicology, 82: 789-802.