Evaluation of the Safety Profile of Ethanol Stem Bark Extract of Mangifera indica on Reproductive Functions of Male Albino Rats

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Aderinola Adeyinka Aderonke
Jane Ejiofor
Olooto Wasiu Eniola
Murtala Abdullahi Akanji
Olawale Oladipupo Olatunbosun

Abstract

Medicinal-plants are widely used globally for prevention and treatment of wide range of diseases. It is sometimes used as alternatives and/or adjuvants to modern-medicine. However, detailed toxicological-evaluation of most herbal-plants especially on Reproductive-functions has not been fully explored. This research focused on evaluating the effect of ethanol stem-bark extract of Mangifera indica on the Hormonal-profile and Semen-quality of male albino rats. Twenty-four male rats weighing between 120-150g each were used for this study. They were divided into 4 groups (A, B, C and D) of six rats per group. Group D served as the control (without test substance) while groups A, B and C were fed with of 250mg/kg, 500mg/kg and 1000mg/kg body-weight (BW) of the extract for the period of 4 weeks and then tested for the hormonal-profile and semen-quality. The results obtained from hormonal analysis showed that the extract produced significant (p<0.05) increase in the levels of Luteinizing hormone-(LH) and Testosterone at 250mg/kg and also produced an increase in Follicle Stimulating hormone-(FSH) level at 1000mg/kg when compared with the control. However, the extract significantly (p<0.05) reduced the levels of Luteinizing hormone-(LH) and Testosterone at 500mg/kg and 1000mg/kg while the level of Follicle Stimulating hormone-(FSH) was reduced at 250mg/kg and 500mg/kg. For the Semen-analysis, the extract significantly (p<0.05) increased the sperm-motility, sperm-morphology and sperm-count of the rats in a dose dependent manner with more pronounced effect at 1000mg/kg when compared with the control, this may be as a result of the ability of the extract to increase the level of Follicle Stimulating hormone-(FSH) which is responsible for spermatogenesis. This suggests that the stem bark of Mangifera indica may be incorporated in the formulation of male fertility drugs.

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How to Cite
Aderonke, A. A. ., Ejiofor, . J., Eniola, O. W. ., Akanji, M. A. ., & Olatunbosun, O. O. . (2020). Evaluation of the Safety Profile of Ethanol Stem Bark Extract of Mangifera indica on Reproductive Functions of Male Albino Rats. Nigerian Journal of Pharmaceutical and Applied Science Research, 8(2), 44–48. Retrieved from http://mail.nijophasr.net/index.php/nijophasr/article/view/289
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Author Biographies

Aderinola Adeyinka Aderonke

Department of Pharmacology and Therapeutics, Olabisi Onabanjo University, Ago-iwoye, Nigeria.

Jane Ejiofor

Department of Pharmacology and Therapeutics, Ahmadu Bello University, Zaria, Nigeria.

Olooto Wasiu Eniola

Department of Chemical Pathology and Immunology, Olabisi Onabanjo University, Ago-iwoye, Nigeria.

Murtala Abdullahi Akanji

Department of Pharmacology and Therapeutics, Olabisi Onabanjo University, Ago-iwoye, Nigeria

Olawale Oladipupo Olatunbosun

Department of Chemical Pathology and Immunology, Olabisi Onabanjo University, Ago-iwoye, Nigeria.

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